According to historical accounts, King Gustav III of Sweden was convinced that drinking coffee was harmful to ones health. In the late 18th century, he sought out to prove its detrimental effects by offering a pair of twins, who had been sentenced to death, commutation of their sentence to life imprisonment on one condition: for the rest of their lives, one twin had to drink three pots of coffee each day, while the other consumed the same amount of tea.
The result was that the tea drinker died before his twin. Because both scholars who supervised the study died before the prisoners, the results remain inconclusive to this day. Nevertheless, this experiment is often regarded as the earliest long-term study in twin research.